Endocrine Abstracts

The hypothalamic melanocortin system is a regulator of energy homeostasis. Chronic CNS administration of Agouti related peptide (Agrp) causes increased food intake, increased body adiposity, an inhibition of the HPT axis and a suppression of BAT UCP-1. The ability of Agrp to alter oxygen consumption, a measure of energy expenditure, is unknown.Chronic daily ICV administration of Agrp (1nmol) caused a 54% increase in food intake (food intake, day 7: Agrp...

Background: Studies across the world have unveiled different prevalence of primary aldosteronism (PA) in distinct geographical areas and human races. However, owing to disparities in methodology and recruitment, the true incidence is still open. Especially information in Asian resistant hypertension is rare, so we determined to investigate the prevalence of PA in this population.Methods: We launched a large-scale, hospital-based national survey and enrol...